The Concept

Dr. Lee Hood: 100K Wellness Project

ISB invented the field of systems biology over the past decade. But how can we foster a new vision that will let us invent a transformational future? One answer to that question is the 100K Wellness Project, pioneered by Dr. Leroy Hood.

(This project) is very exciting because conceptually and technically, it's reached a real tipping point where we're in a position to fundamentally change how healthcare is practiced.

--Dr. Leroy Hood, President, ISB

We are at a tipping point

Four Phases of the 100K Wellness Project: Starting with Pioneer 100

Four Phases

Pioneer 100: An Overview of What Will Be Monitored

Project Team

  • Lee Hood, MD, PhD
  • Nathan Price, PhD
  • Gustavo Glusman, PhD
  • Chris Witwer
  • John C. Earls
  • Kristin Brogaard, PhD
  • Andrew Magis, PhD
  • Clayton Lewis
  • Jennifer Lovejoy, PhD
  • Sara Mecca
  • Gretchen Sorensen
  • Mary Brunkow, PhD
  • Sandi Kaplan, MS, RD
  • Sean Bell

P4 At A Glance

Predictive, Preventive, Personalized & Participatory: P4 Medicine

  • P4 Medicine is proactive.
  • P4 Medicine focuses on the individual patient.
  • P4 Medicine places major emphasis on maintaining and enhancing wellness.

  • P4 Medicine generates patient data clouds of billions of data points.
  • P4 Medicine realizes that each patient is genetically and environmentally unique.
  • Consumer activated social networks will be a major driving force for gaining acceptance of P4 Medicine.


Systems Biology + P4 Medicine

Systems biology will revolutionize the practice of healthcare in the coming decades. Today, medicine is largely reactive. It waits until a person is sick and then treats a disease, with varying levels of success. The revolution will emerge from the convergence of systems biology and the digital revolution’s ability to create consumer devices, generate and analyze “big data” sets and deploy this information through business and social networks.

By providing an understanding of disease at the molecular level, systems medicine will eventually be able to predict when an organ will become diseased or when a perturbation in a biological network could progress to disease. Alterations in biological networks can be reflected in the structure, quantity, or location of the proteins making up those networks. For example, ISB researchers have been developing tests that can flag the presence of particular cancers by detecting proteins in the blood, allowing those cancers to be treated at an early stage. As more such tests are developed, the proteins in blood could reveal the health status of every major organ in the body, enabling detailed predictions of disease causation and progression.

The ability to predict and prevent disease will in turn make it possible to personalize medicine. Within a few years, it will be possible to sequence an individual’s genome for less than a thousand dollars. The DNA differences between individuals contribute to not only their unique physical characteristics but also to their differing susceptibility to disease. Medicine will be able to take into account how these DNA differences -- along with each person’s environmental exposures and experiences -- influence an individual’s biological systems. The result will be personalized predictions of disease and personalized treatments to prevent disease.

Realizing the promise of P4 medicine will require -- and will drive -- profound economic, policy, and social changes.

P4 medicine also will require new standards and new policies for handling biological and health care information about individuals. Genomes may contain information that people wish to keep private, and predictions of future health status raise complex questions about how much people want to know or want their insurance companies to know. Complex data sets will need to be handled securely and interpreted knowledgeably and thoroughly.

P4 medicine has a number of interesting implications. First, the development of systems approaches together with pioneering new technologies (individual genome sequencing, measurement of thousands of blood proteins from a fraction of a droplet of blood) and new computational and mathematical tools will lead to a digitalization of medicine. Namely, the ability to obtain disease-relevant information from single molecules, single cells or single individuals. This will lead within 10 years to billions of data points for each individual patient. How one reduces this enormous data dimensionality to simple hypotheses about health and disease is one of the grand challenges of computational medicine.

Third, P4 medicine will necessitate a fundamental change in the business plans of virtually every sector of the health care industry over the next 10 years. This will provide challenges to existing companies and opportunities to create new companies specialized in the needs of P4 medicine.


Research Publications

Hood L, Price ND. May 15, 2014. Promoting Wellness and Demystifying Disease: The 100K Wellness Project. Clinical Omics.

Hood L, Price N. 2014. Demystifying Disease, Democratizing Healthcare. Science Translational Medicine. 26 February 2014: Vol. 6 no. 225 pp. 225ed5. DOI:10.1126/scitranslmed.3008665

Hood L, Auffray C. 2013. Participatory Medicine Is Revolutionizing Healthcare. Genome medicine. 5:110.

Flores M, Glusman G, Brogaard K, Price ND, Hood L. 2013. P4 medicine: how systems medicine will transform the healthcare sector and society. Personalized Medicine. 10:6, 565-576.

Hood L. 2013. Inventing the Future. Institute for Systems Biology. 2012 Annual Report.

Hood L. 2013. Systems Biology and P4 Medicine: Past, Present, and Future. Rambam Maimonides Med J. 4(2):e0012.

Latest Press

In The News

Lash, A. September 23, 2014. “100K” Marathon: A Decades-Long Health Study Makes Its Business Case. Xconomy.

Hood L, Price ND. May 15, 2014. Promoting Wellness and Demystifying Disease: The 100K Wellenss Project. Clinical Omics.

Biome Magazine Q&A with Lee Hood. April 15, 2014. Leroy Hood on participatory medicine: future benefits and challenges ahead. Genome Medicine.

Cunha, A. April 10, 2014. Participatory Medicine Podcast. Genome Medicine.

Ray, T. 2014. Hood Lays out 100K-Patient Longitudinal Research Agenda to Spur Wellness Industry in Next Decade. Genome Web.

DelViscio, J. 2014. The Virtual Self. Science Times Podcast, Feb. 17, 2014 The New York Times. 2014 A Wellness Project to Assess the Impact of Digital Devices on Health. Nuviun Digital Health.

Sheridan, K. 2014 100 people commit their bodies to science in new study. Agence France-Presse via Yahoo! News.

Gibbs, W. 2014. Medicine Gets Up Close and Personal. Nature.

Bauman V. 2013. Health Care of the Future. Puget Sound Business Journal.